Calcium Disorders Treatment

Calcium disorders refer to conditions characterized by abnormal levels of calcium in the blood. Calcium plays a crucial role in various physiological processes, including bone health, muscle function, nerve transmission, and blood clotting. The normal range of calcium in the blood is typically between 8.5 to 10.5 milligrams per deciliter (mg/dL).

Symptoms of calcium disorders can vary depending on whether the levels are too high or too low. Hypercalcemia symptoms may include excessive thirst, frequent urination, abdominal pain, muscle weakness, fatigue, confusion, and kidney stones. Symptoms of hypocalcemia may include muscle cramps, twitching, numbness or tingling in the extremities or around the mouth, seizures, and abnormal heart rhythms. Treatment for calcium disorders aims to address the underlying cause. This may involve medications to regulate hormone levels, dietary adjustments, vitamin or mineral supplements, or other specific interventions depending on the individual's condition.


Endocrinologist Dr. Naincy Purwar specializes in the diagnosis and management of calcium disorders, depending on the specific condition and its underlying cause. She is skilled in treatment of hormone-related disorders. Since calcium regulation involves hormones such as parathyroid hormone (PTH) and calcitonin, Dr. Naincy Purwar often play a central role in the management of hypercalcemia and hypocalcemia, especially when they are related to disorders of the parathyroid glands. In many cases, a multidisciplinary approach involving several specialists may be necessary to provide comprehensive care.


There are two primary types of calcium disorders:

1. Hypercalcemia:

This occurs when the calcium levels in the blood are too high, generally above 10.5 mg/dL. Hypercalcemia can result from various underlying conditions, including:

  • Hyperparathyroidism: Overactivity of the parathyroid glands, which regulate calcium levels.
  • Certain cancers: Such as lung, breast, kidney, or multiple myeloma, which can release calcium into the bloodstream.
  • Excessive intake of calcium or vitamin D supplements.
  • Certain medications: Such as thiazide diuretics, which can increase calcium levels.
  • Prolonged immobilization or bed rest.

2. Hypocalcemia:

This occurs when calcium levels in the blood are too low, typically below 8.5 mg/dL. Hypocalcemia can result from various causes, including:

  • Hypoparathyroidism: Underactivity of the parathyroid glands, leading to reduced calcium levels.
  • Vitamin D deficiency: Vitamin D is essential for calcium absorption in the intestines.
  • Chronic kidney disease: Impaired kidney function can lead to decreased calcium levels.
  • Magnesium deficiency: Magnesium is necessary for the proper functioning of parathyroid hormone, which regulates calcium levels.
  • Certain medications: Such as bisphosphonates or antiepileptic drugs, which can lower calcium levels.


Here's an overview of treatment approaches for both conditions:

1. Hypercalcemia Treatment:

  • Hydration: Intravenous fluids are often administered to help flush excess calcium from the body through urine.
  • Medications: Depending on the underlying cause of hypercalcemia, medications may be prescribed to lower calcium levels. These may include:
  • 1. Bisphosphonates: Drugs such as zoledronic acid or pamidronate inhibit bone breakdown and reduce calcium release from bones.
  • 2. Calcitonin: This hormone can help reduce calcium levels by inhibiting bone resorption.
  • 3. Glucocorticoids: Steroids like prednisone may be used to lower calcium levels, particularly in cases of granulomatous diseases.
  • 4. Denosumab: A monoclonal antibody that inhibits bone resorption by blocking the activity of a protein involved in bone breakdown.
  • Treatment of Underlying Conditions: If hypercalcemia is due to an underlying medical condition such as hyperparathyroidism, cancer, or granulomatous diseases, treating the primary cause is essential.
  • Dietary Changes: In some cases, dietary adjustments may be recommended to limit calcium intake.

2. Hypocalcemia Treatment:

  • Calcium Supplementation: Oral calcium supplements may be prescribed to raise calcium levels in individuals with hypocalcemia. These supplements often contain calcium carbonate or calcium citrate.
  • Vitamin D Supplementation: Since vitamin D is necessary for calcium absorption, supplements may be prescribed to individuals with hypocalcemia, particularly if the deficiency is contributing to the condition.
  • Medications: In cases where hypocalcemia is due to underlying conditions such as hypoparathyroidism, medications may be prescribed to manage the disorder. These may include:
  • 1. Calcium-sensing receptor agonists: Drugs like cinacalcet can help increase sensitivity to calcium in tissues, reducing the need for PTH.
  • 2. In some cases, a synthetic form of PTH may be used to increase calcium levels.
  • Treatment of Underlying Conditions: Addressing the underlying cause of hypocalcemia is crucial. This may involve treating vitamin D deficiency, managing chronic kidney disease, or addressing other contributing factors.
  • Monitoring: Regular monitoring of calcium levels through blood tests is important to ensure that treatment is effective and to prevent complications associated with both hypercalcemia and hypocalcemia.

Treatment plans for calcium disorders should be tailored to individual patients based on factors such as the severity of the condition, the underlying cause, and any coexisting medical conditions. Close collaboration between patients and Endocrinologist Dr. Naincy Purwar is essential for optimal management and monitoring of calcium disorders.


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